RAD-150 (TLB-150 Benzoate)

RAD-150 (Test 2.0) – Next-Generation SARM: Technical Profile

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1. Compound Overview

Core Specifications

• IUPAC Name: (R)-2-chloro-4-[(1R)-1-(4-cyanophenyl)ethyl]piperazine-1-carboxamide
• Molecular Formula: C16H25ClN2OC16​H25​ClN2​O
• CAS Number: 1182367-47-1
• Class: Selective Androgen Receptor Modulator (SARM)
• Bioavailability: 78% (oral administration)
• Concentration: 25 mg/ml (30 ml solution)

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2. Mechanism of Action

RAD-150 demonstrates tissue-selective anabolic activity through:

1. AR Partial Agonism: Binds androgen receptors in muscle/bone (EC₅₀ = 2.8 nM) with 12:1 muscle-to-prostate selectivity
2. Myostatin Inhibition: Downregulates TGF-β signaling pathway (+18% muscle fiber cross-sectional area)
3. Neuroprotective Effects: Activates AR-mediated BDNF synthesis in CNS tissues
4. Bone Remodeling: Stimulates osteoblast differentiation via Wnt/β-catenin pathway

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3. Research Applications

Experimental Outcomes

Application	Model System	Observed Results
Muscle Hypertrophy	Resistance-trained primates	14.3% lean mass gain (8-week cycle)
Bone Density	Ovariectomized rat models	9.2% increase in femoral BMD
Neuroprotection	TBI mouse models	37% reduction in neuronal apoptosis
Recovery Enhancement	Eccentric exercise studies	22% faster strength recovery vs placebo

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4. Product Advantages

Key Differentiators

1. Tissue Selectivity: Minimal prostate/visceral AR activation
2. Cognitive Benefits: Unique neuroactive properties among SARMs
3. Bone Health: Dual action on muscle and skeletal systems
4. Stack Versatility: Complements $YK-11$ (myostatin inhibition) and $MK-677$ (GH secretion)

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5. Quality Assurance

• Manufacturing: UK GMP-certified facility (MHRA inspected)
• Purity: 99.2% HPLC-verified (residual solvent <0.1%)
• Stability: 24-month shelf life (stored at 15–25°C in amber vials)
• Packaging: Nitrogen-flushed vials with PTFE-lined caps

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6. Experimental Guidelines

Dosing Protocol

• Oral Administration: 10–25 mg/day (split AM/PM dosing)
• Cycle Duration: 8–10 weeks (aligns with myonuclei accretion cycles)
• Stacking Strategies:
  • +Cardarine: Enhances fatty acid oxidation during cuts
  • +Ostarine: Synergistic lean mass preservation
  • +Andarine: Joint support during heavy loading phases

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7. Safety Profile

Key Considerations

• Androgen Suppression: Mild HPTA axis suppression at >20 mg/day doses
• Hepatotoxicity: No ALT elevation in primate studies
• CNS Penetration: Cerebrospinal fluid concentration reaches 12% of plasma levels

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8. Comparative Analysis

Parameter	RAD-150	RAD-140	LGD-4033
Anabolic Ratio	8:1	9:1	10:1
Half-Life	16h	20h	24h
Bone Effects	⭐⭐⭐⭐	⭐⭐	⭐
CNS Activity	⭐⭐⭐	⭐	⭐

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9. Research Recommendations

1. Aging Research: Investigate sarcopenia reversal in geriatric models
2. Trauma Recovery: Combined use with $BPC-157$ for tissue repair
3. Cognitive Studies: Impact on neurodegenerative disease progression

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10. Company Guarantees

• Shipping: Free next-day UK delivery / tracked global shipping
• Testing: Third-party mass spec verification available
• Support: 24/7 access to SARM research specialists
• Satisfaction: 90-day performance-based refund policy