TB500

TB500: Peptide for Advanced Tissue Recovery and Regeneration

Overview

Product Contents:

• 1x TB500 5 mg Vial
• 1x Bacteriostatic Water for Injection (with Benzyl Alcohol)

TB500 is a synthetic peptide derived from Thymosin Beta-4, crucial for cellular repair and regeneration. It is designed for stability and efficiency, replicating the biological activity of Thymosin Beta-4 while offering advantages in shelf life and usability. Each vial contains 5 mg of TB500 in lyophilized powder form, intended strictly for laboratory research and not for human or veterinary use.

Scientific Background

Thymosin Beta-4 is prevalent in nearly all human and animal cells, especially at tissue injury sites. It plays significant roles in:

• Wound healing
• Inflammation reduction
• Angiogenesis (formation of new blood vessels)

TB500 is a smaller, synthetically optimized fragment of Thymosin Beta-4, focusing on actin regulation to provide a targeted compound for laboratory studies.

Mechanism of Action

TB500 primarily promotes the polymerization of actin, essential for the cytoskeleton of all cells. This regulation aids in:

• Cell movement
• Structural repair

Other observed mechanisms include:

• Enhanced migration of stem and repair cells to damaged tissues
• Stimulation of angiogenesis, improving blood supply to injured areas
• Downregulation of inflammatory cytokines for faster recovery
• Support for nerve and muscle cell regeneration

TB500 shows potential in models of ocular damage, cardiovascular repair, and soft-tissue injuries, making it increasingly relevant across various fields of study.

Research Applications

TB500 has been explored in preclinical research for its healing and regenerative properties. Common applications include:

1. Musculoskeletal Repair
   • Accelerates recovery of skeletal muscle, tendons, and ligaments post-injury.
   • Stimulates satellite cell activation and reduces fibrotic tissue buildup.
2. Cardiovascular Regeneration
   • Evaluated for angiogenic and anti-fibrotic properties in cardiac models.
   • Increases vascular endothelial growth factor (VEGF) expression.
3. Wound Healing and Skin Recovery
   • Accelerates epithelialization and collagen deposition in dermal wound healing.
4. Joint and Tendon Health
   • Reduces swelling and improves flexibility in arthritis models.
5. Nervous System Repair
   • Supports axonal regrowth and remyelination, indicating potential in spinal cord injury models.

Product Details

• Compound: TB500 (Thymosin Beta-4 fragment)
• Molecular Formula: C212H350N56O78S
• Molecular Weight: ~4963.5 g/mol
• Unit Size: 5 mg
• Appearance: White lyophilized powder
• Purity: ≥99% (HPLC verified)
• Packaging: Sterile, light-resistant vial
• Storage (unreconstituted): -20°C
• Storage (reconstituted): Refrigerate at 2–8°C and use within 20 days
• Solubility: Soluble in bacteriostatic or sterile water

Chemical Identifiers

• CAS Number: 885340‑08‑9
• PubChem CID: 62707662
• UNII: QHK6Z47GTG

Handling & Reconstitution

TB500 is provided in lyophilized form and must be reconstituted before use. Use bacteriostatic water for injection to maintain sterility. Gently swirl the vial until fully dissolved—do not shake vigorously. Always follow aseptic techniques and proper laboratory safety protocols.

Lab Use Only: Not for Human Consumption

This compound is strictly for laboratory research use only and is not intended for therapeutic or diagnostic applications. Improper use is prohibited, and by purchasing, you confirm compliance with relevant research guidelines and safety standards.

Comparison: TB500 vs Full-Length Thymosin Beta-4

Feature	TB500	Thymosin Beta-4
Molecular Size	17 amino acids	43 amino acids
Research Stability	High	Moderate
Focused Action	Yes (targeted actin segment)	Broader biological activity
Cost Efficiency	More affordable per dose	Higher cost per unit
Common in Research Models	Yes	Less common due to instability

Storage Guidelines

• Unreconstituted: Store in a dark, frozen environment (-20°C).
• Reconstituted: Refrigerate (2–8°C) and use within 20 days.
• Avoid repeated freeze-thaw cycles to prevent degradation.

Purity & Quality Assurance

TB500 is manufactured in GMP-compliant laboratories and independently tested. Each batch includes a Certificate of Analysis verifying:

• Amino acid sequence
• Peptide mass (MS)
• Purity (HPLC)
• Solubility
• pH and sterility

Frequently Asked Questions

• Is this product legal?
  Yes, TB500 is legal for laboratory research purposes but not approved for human consumption.
• How long does it last after reconstitution?
  Best used within 20 days when stored properly.
• Do you provide documentation?
  Yes, each order includes a Certificate of Analysis and lab-grade reference data.
• Can TB500 be shipped internationally?
  We ship to most countries, but compliance with local regulations is your responsibility.

Why Choose Us?

• ✔️ Research-grade quality backed by documentation
• ✔️ Tamper-proof packaging for product integrity
• ✔️ Responsive support from experienced staff
• ✔️ Discreet shipping worldwide
• ✔️ Bulk pricing available for institutions and labs

Order TB500 (5 mg): Research-Grade Peptide

TB500 is one of the most versatile peptides studied for tissue repair, wound healing, and anti-inflammatory research. With reliable quality, detailed documentation, and professional service, we support your lab’s goals every step of the way.