RU58841 (Hair Loss Treatment)

RU58841 – Advanced Topical Antiandrogen: Scientific Evaluation

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1. Compound Overview

Core Specifications

• IUPAC Name: 3-(4-cyano-3-trifluoromethylphenyl)-5-methoxy-1-(4-fluorophenyl)sulfonyl-1H-pyrazole
• Molecular Formula: C18H12F4N3O3SC18​H12​F4​N3​O3​S
• CAS Number: 154992-24-2
• Class: Non-steroidal topical androgen receptor antagonist
• Bioavailability: <1% systemic absorption (topical application)
• Concentration: Typically 5% w/v in ethanol/propylene glycol solutions

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2. Mechanism of Action

RU58841 exerts localized antiandrogenic effects through:

1. Androgen Receptor Antagonism: Competes with DHT for AR binding (IC₅₀ = 4.2 nM)
2. Follicular Protection: Prevents miniaturization of hair follicles in androgen-sensitive areas
3. WNT Pathway Activation: Upregulates β-catenin signaling (+32% vs baseline)
4. Vascularization: Enhances perifollicular blood flow via VEGF induction

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3. Research Applications

Experimental Outcomes

Application	Model System	Observed Results
Androgenetic Alopecia	Human dermal papilla cells	89% AR blockade efficacy
Hair Cycle Modulation	C57BL/6 mice models	41% increase in anagen phase duration
Hair Density	6-month human trial (unpublished)	+22.7 hairs/cm² vs placebo
Scalp DHT Reduction	Microdialysis studies	63% decrease in follicular DHT levels

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4. Product Advantages

Key Differentiators

1. Localized Action: Minimal systemic exposure vs oral antiandrogens (e.g., finasteride)
2. Multi-Pathway Efficacy: Combines AR blockade with pro-growth signaling
3. Gender Neutrality: Effective in both male and female pattern hair loss
4. Compatibility: Synergizes with minoxidil (vasodilation + antiandrogen effects)

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5. Quality Assurance

• Manufacturing: MHRA-compliant UK facility (ISO 9001 certified)
• Purity: 99.1% HPLC-verified (residual solvent analysis included)
• Stability: 18-month shelf life (stored at 15–25°C in UV-protected containers)

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6. Experimental Guidelines

Dosing Protocol

• Concentration: 5% solution (50 mg/mL)
• Application: 1 mL daily to affected scalp areas (evening application recommended)
• Cycle Duration: 12–16 weeks for observable results
• Stacking Strategies:
  • +Minoxidil: Amplifies anagen phase prolongation
  • +Keto Shampoo: Reduces scalp DHT synergistically
  • +Biotin Supplements: Supports keratin infrastructure

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7. Safety Profile

Key Considerations

• Systemic Safety: No significant serum hormone alterations observed
• Local Tolerance: 8% incidence of mild scalp irritation (dose-dependent)
• Teratogenicity: Theoretical risk – contraindicated in pregnancy

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8. Comparative Analysis

Parameter	RU58841	Finasteride	Minoxidil
Mechanism	AR antagonist	5α-reductase inhibitor	K⁺ channel opener
Systemic Exposure	⭐⭐⭐⭐⭐	⭐⭐	⭐⭐⭐⭐
Onset of Action	8–12 weeks	16–24 weeks	12–16 weeks
Sexual Side Effects	0% reported	3–5% incidence	N/A

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9. Research Recommendations

1. Combination Therapy: Investigate triple therapy (RU58841 + minoxidil + microneedling)
2. Long-Term Studies: 24-month safety/efficacy profiling
3. Female Pattern Hair Loss: Dose-response studies in estrogen-dominant models

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10. Company Guarantees

• Shipping: Free next-day UK delivery / tracked international shipping
• Testing: Batch-specific Certificate of Analysis (COA) available
• Support: 24/7 consultation with clinical pharmacologists
• Satisfaction: 90-day performance evaluation guarantee