IGF-1 LR3

IGF-1 LR3 Overview

IGF-1 LR3 is a synthetic analogue of insulin-like growth factor 1 (IGF-1), distinguished by an additional 13 amino acids at the N-terminus, resulting in a total of 83 amino acids. This structural modification enhances its biological activity, increasing its affinity for IGF-1 receptors while decreasing its binding to IGF-binding proteins. This allows IGF-1 LR3 to remain in its active form, effectively binding to IGF-1 receptors.

Mechanism of Action

IGF-1 LR3 acts similarly to IGF-1 by binding to IGF-1 receptors, triggering several intracellular signaling pathways, including PI3K/AKT and MAPK. The activation of these pathways leads to:

• Promotion of Glucose Uptake: Enhances glucose utilization in cells.
• Increased Energy Production: Boosts cellular energy generation.
• Enhanced Glycolysis: Improves the breakdown of glucose for energy.
• Increased Protein and Lipid Synthesis: Supports the creation of proteins and lipids.
• Coordination of Nutrient Uptake: Optimizes nutrient absorption.
• Cell Proliferation and Differentiation: Stimulates cell growth and development.
• Gene Expression Changes: Promotes processes that support cell cycle progression and tissue growth.

Therapeutic Potential

IGF-1 LR3 has been investigated for its potential therapeutic applications, including:

1. Wounds and Injuries:
   • Supports tendon and nerve regeneration, promoting angiogenesis and tissue repair while reducing inflammation.
2. Neurodegenerative Diseases:
   • May protect against neurodegeneration and promote neurogenesis, preserving motor functions.
3. Nerve-Related Problems:
   • Aids in the regeneration of nerves after damage, which can be beneficial for peripheral nerve injuries and neuropathic pain management.
4. Obesity and Metabolic Disorders:
   • Regulates adipose tissue metabolism, improves insulin sensitivity, and enhances glucose metabolism.
5. Muscle Wasting Conditions:
   • Stimulates protein synthesis and muscle satellite cell proliferation, counteracting muscle loss and supporting muscle regeneration.
6. Cardiovascular Issues:
   • Promotes growth and survival of heart muscle cells, potentially improving heart function after events like myocardial infarction.

Safety Considerations

While animal studies have shown promising therapeutic benefits of IGF-1 LR3, human studies are limited. There are concerns that its activation pathways may inadvertently promote the growth of existing cancer cells.

Data Sheet

• Application: Research on tissue repair, growth, neuroprotection, and metabolism
• CAS Number: 946870-92-4
• Molar Mass: 9,118 Da
• Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
• Chemical Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Synonyms: Long Arginine 3-IGF-1, LR3 IGF-1, IGF-1 LR3
• Storage: Refrigerate at 2-8°C until use; for long-term storage, keep at -20°C.
• Reconstitution: Reconstitute in sterile water; stable for up to one week at 2-8°C.
• Organoleptic Profile: White to off-white lyophilized powder
• Physical Form: Solid

Conclusion

IGF-1 LR3 activates IGF-1 receptors, leading to beneficial effects such as increased cell growth, survival, and metabolic regulation. Most of the current knowledge about IGF-1 LR3 comes from in vitro and animal studies. Further human studies are necessary to clarify its therapeutic potential and safety profile.